Peer-reviewed veterinary case report
Intraperitoneal atrial natriuretic peptide attenuates anxiety-related behaviour during alcohol withdrawal in mice.
- Journal:
- Pharmacopsychiatry
- Year:
- 2014
- Authors:
- von der Goltz, C et al.
- Affiliation:
- Department of Addictive Behaviour and Addiction Medicine · Germany
- Species:
- rodent
Abstract
Converging evidence from both preclinical and clinical studies suggests atrial natriuretic peptide (ANP) as a potential target for treatment of alcohol withdrawal and dependence. Since ANP tightly interacts with hypothalamic-pituitary-adrenocortical (HPA) axis activity, especially the modulation of stress-related anxiety during alcohol withdrawal might mediate these effects. We have now evaluated the anxiolytic activity of intraperitoneal ANP application during alcohol withdrawal in alcohol-habituated mice (C57/Bl6J). Anxiety related behaviour was attenuated during ethanol withdrawal following application of ANP (60 μg/kg) vs. saline. Our results support that anxiolytic effects of ANP mediate ANP-related gene effects with clinical data on withdrawal symptomatology.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24846084/