Peer-reviewed veterinary case report
Intraspecies transmission of L-type-like Bovine Spongiform Encephalopathy detected in Japan.
- Journal:
- Microbiology and immunology
- Year:
- 2009
- Authors:
- Fukuda, Shigeo et al.
- Affiliation:
- Molecular Biotechnology Laboratory · Japan
Abstract
It has been assumed that the agent causing BSE in cattle is a uniform strain (classical BSE); however, different neuropathological and molecular phenotypes of BSE (atypical BSE) have been recently reported. We demonstrated the successful transmission of L-type-like atypical BSE detected in Japan (BSE/JP24 isolate) to cattle. Based on the incubation period, neuropathological hallmarks, and molecular properties of the abnormal host prion protein, the characteristics of BSE/JP24 prion were apparently distinguishable from the classical BSE prion and closely resemble those of bovine amyloidotic spongiform encephalopathy prion detected in Italy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19954458/