Peer-reviewed veterinary case report
Stem cell treatment tested in paraplegic dogs with no deep pain
By Besalti, Omer et al.·Published in Turkish neurosurgery·2015·Ankara University·View original on PubMed →
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Original publication title: Intraspinal Transplantation of Autologous Neurogenically-Induced Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Paraplegic Dogs without Deep Pain Perception Secondary to Intervertebral Disk Disease.
- Species:
- dog
Plain-English summary
Seven dogs with severe back problems due to intervertebral disk disease (IVDD) were unable to walk and had no deep pain perception. They received injections of their own bone marrow-derived stem cells into their spinal cords to see if it could help them regain movement. After two months, there was little change, but by four months, five dogs showed some improvement in their ability to walk, and by eight months, three dogs had better movement and sensation. This treatment may offer hope for dogs with poor recovery chances after IVDD.
People also search for: dog paraplegic treatment · intervertebral disk disease stem cell therapy · dog back problems recovery
Abstract
AIM: To investigate the effects of neurogenically-induced autologous bone marrow-derived mesenchymal stem cells (NIBM-MSCs) in paraplegic dogs without deep pain perception (DPP) secondary to intervertebral disk disease (IVDD). MATERIAL AND METHODS: Seven dogs which could not be improved neurologically with conventional treatment modalities were included in the study. All dogs were diagnosed by magnetic resonance imaging and surgically treated. Each dog received two times a suspension of autologous 5.0x106 NIBM-MSCs, which were positive to CNPase and MAP-2, as well as to GFAP and beta III tubulin into the spinal cord through the hemilaminectomy defect percutaneously, with a 21-day interval. RESULTS: Two months after cell transplantation, there were no changes except for 1 gait score improvement for 1 of the cases. At the 4th month, gait score had improved 1 score in 5 cases, and one score progress was recorded in proprioception and nociception in 1 case. In eight months-followed up 4 cases were evaluated by the same parameter; gait score had improved in 3 cases, and propriception improved in 2 cases, and nociception improved in 3 cases. CONCLUSION: Our findings suggest that utility of autologous NIBM-MSCs for cases with poor prognosis after IVDD can be a promising approach.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26242341/