Peer-reviewed veterinary case report
Intravenous docetaxel side effects in cats with cancer
By Shiu, K B et al.·Published in Journal of veterinary internal medicine·2011·Department of Medical Sciences, United States·View original on PubMed →
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Original publication title: Intravenous administration of docetaxel to cats with cancer.
- Species:
- cat
Plain-English summary
Twenty-one cats with cancer were treated with an intravenous medication called docetaxel to see how well they tolerated it. Most cats received between one and five treatments, and while some experienced side effects like fever, low white blood cell counts, and vomiting, these were generally mild and not very common. The highest safe dose was found to be 2.25 mg/kg. Overall, docetaxel can be given to cats with cancer with a low risk of serious side effects, making it a potential treatment option.
People also search for: cat cancer treatment docetaxel · side effects of docetaxel in cats · intravenous chemotherapy for cats
Abstract
BACKGROUND: The safety of i.v. administration of docetaxel to cats with cancer has not been reported. OBJECTIVES: Document adverse effects of i.v. administration of docetaxel to cats. ANIMALS: Twenty-one client-owned cats with any confirmed malignancy. METHODS: Cats received up to 5 docetaxel treatments, administered i.v. every 3 weeks. The initial dosage was 1.0 mg/kg, and dosages were increased by increments of 0.25 mg/kg in cohorts of 3 cats. Adverse events were determined by a CBC at days 7 and 21, serum chemistry and urine specific gravity at day 21, and medical histories provided by the owners. RESULTS: Cats received docetaxel dosages ranging from 1.0 to 2.5 mg/kg, for a median of 2 treatments. Dose-limiting toxicoses included fever, neutropenia, and vomiting, seen in 2 of the 4 cats treated at 2.5 mg/kg. Hypersensitivity reactions were infrequent (4 of the 21 cats) and mild. The maximum tolerated dosage was 2.25 mg/kg. CONCLUSIONS AND CLINICAL IMPORTANCE: Docetaxel can be administered i.v. to cats with a low incidence of adverse effects.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21615496/