Peer-reviewed veterinary case report
Dog with Pseudomonas urinary infection treated by bladder amikacin
By Torres, Ahmira R & Cooke, Kirsten·Published in Journal of the American Veterinary Medical Association·2014·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Intravesical instillation of amikacin for treatment of a lower urinary tract infection caused by Pseudomonas aeruginosa in a dog.
- Species:
- dog
Plain-English summary
A 9-year-old neutered male Golden Retriever was brought in due to a recurring lower urinary tract infection, which was causing his urine to smell bad. Tests showed he had an infection from a tough bacteria called Pseudomonas aeruginosa, but it was treatable with a medication called amikacin. After initially receiving amikacin injections, the treatment switched to directly instilling amikacin into his bladder. This approach successfully cleared the infection, and follow-up tests showed no signs of bacteria or other issues in his urine. However, he did experience some blood in his urine, which went away after stopping the treatment.
People also search for: dog urinary tract infection treatment · Golden Retriever smelly urine · amikacin for dog bladder infection
Abstract
CASE DESCRIPTION: A 9-year-old neutered male Golden Retriever was evaluated because of recurrent lower urinary tract infection subsequent to placement of a permanent cystostomy tube. CLINICAL FINDINGS: The dog was clinically normal except for the presence of malodorous urine. Bacteriologic culture of a urine sample obtained by cystocentesis yielded growth of Pseudomonas aeruginosa, which was susceptible to amikacin, gentamicin, imipenemcilastatin, and ticarcillin-clavulanic acid. TREATMENT AND OUTCOME: The dog was administered amikacin sulfate (15 mg/kg [6.8 mg/lb], SC, q 24 h) for 14 days before treatment was discontinued because of the presence of casts in the urine. The cystostomy tube was replaced, and intravesical instillation of amikacin (15 mg/kg diluted in 30 mL of saline [0.9% NaCl] solution, q 12 h) was initiated. On day 25 of instillation treatment, bacterial culture of a urine sample yielded no growth, urinalysis revealed no casts, and SUN and creatinine concentrations were within reference intervals. On day 27 of instillation treatment, gross hematuria was observed, which resolved following discontinuation of amikacin instillation. CLINICAL RELEVANCE: In this dog, treatment of a lower urinary tract infection caused by a multidrug-resistant strain of P aeruginosa was successfully achieved with intravesical instillation of amikacin. Results of serial serum biochemical analyses remained within reference limits, and urine casts were not identified on urinalyses during the treatment period, which suggested that systemic absorption of amikacin was minimal. Intravesical instillation of antimicrobials may be a viable treatment option for dogs with lower urinary tract infections caused by multidrug-resistant bacteria.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25229532/