Peer-reviewed veterinary case report
Intravitreal anakinra inhibits choroidal neovascular membrane growth in a rat model.
- Journal:
- Ocular immunology and inflammation
- Year:
- 2009
- Authors:
- Olson, Jeffrey L et al.
- Affiliation:
- University of Colorado Denver · United States
- Species:
- rodent
Abstract
PURPOSE: To determine the effect of intravitreal anakinra on choroidal neovascularization (CNV) in an animal model. METHODS: Laser photocoagulation used to rupture Bruch's membrane; animals then assigned to groups based on varying frequency of intravitreal anakinra injections. At day 30, digital angiography was used to measure the CNV area. RESULT: Intravitreal anakinra dose-dependently inhibited CNV growth. Injections given one time resulted in a 26% reduction in CNV; in the once weekly group, a 41% reduction was seen; in the twice-weekly group, a 62% reduction was seen (all p < .001). CONCLUSION: Suppressing IL-1 function may provide another therapeutic avenue in exudative AMD.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19585363/