Peer-reviewed veterinary case report
Cidofovir injection to reduce eye pressure in dogs after retinal
By Kim, Sunhyo & Shim, Jaeho·Published in Veterinary ophthalmology·2026·Ilsan Animal Medical Center, South Korea·View original on PubMed →
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Original publication title: Intravitreal Cidofovir Injection for Refractory End-Stage Glaucoma and Vision Loss in Silicone Oil-Filled Eyes Following Retinal Reattachment Surgery in Dogs: Four Cases.
- Species:
- dog
Plain-English summary
A 7-year-old mixed-breed dog with severe glaucoma and vision loss after retinal surgery received an injection of cidofovir directly into the eye to help manage pain and pressure. Following the treatment, the dog's eye pressure dropped significantly, and the owner reported that the dog was much more comfortable. While some mild side effects like eye discharge and redness occurred, they were easily treated with medication. Overall, the owner was pleased with the improvement in their dog's comfort and the appearance of the eye.
People also search for: dog glaucoma treatment · cidofovir injection for dogs · managing eye pressure in dogs · dog vision loss after surgery · palliative care for dog eye problems
Abstract
OBJECTIVE: To describe the clinical outcome of intravitreal cidofovir injection for palliative management of refractory end-stage glaucoma and vision loss in silicone oil-filled eyes following retinal reattachment surgery in dogs. PROCEDURES: Medical records of dogs that underwent a single intravitreal cidofovir injection for pharmacologic ciliary body ablation were retrospectively reviewed. Data collected included clinical history, intraocular pressure (IOP), post-injection ocular comfort, complications, and follow-up duration. RESULTS: Four dogs (four eyes) were included. All treated eyes demonstrated a marked reduction in IOP at the first post-injection recheck (14-28 days after injection; post-injection IOP range: 3-7 mmHg). Adequate pain control was achieved in all dogs throughout the follow-up period (median follow-up: 306.5 days; range: 40-369 days). Progressive phthisis bulbi developed in one case at long-term follow-up, while the remaining eyes maintained acceptable globe integrity and cosmetic appearance. Moderate to severe post-injection ocular discharge, conjunctival hyperemia, and aqueous flare were observed in all cases and were manageable with routine topical therapy. All owners reported satisfaction with post-injection comfort and appearance. CONCLUSIONS: A single intravitreal cidofovir injection may represent a feasible palliative option for controlling intraocular pressure and ocular pain in silicone oil-filled eyes with refractory glaucoma when enucleation is declined. Further studies are needed to better characterize long-term safety and outcomes in this clinical setting.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/42046189/