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Peer-reviewed veterinary case report

INTRODUCTION: Immune Relevant Animal Models: Opportunities and Challenges.

Journal:
ILAR journal
Year:
2018
Authors:
Jungersen, Gregers & Piedrahita, Jorge
Affiliation:
Department of Health Technology

Abstract

Valid interpretation of preclinical animal models in immunology-related clinical challenges is important to solve outstanding clinical needs. Given the overall complexity of the immune system and both species- and tissue-specific immune peculiarities, the selection and design of appropriate immune-relevant animal models is, however, not following a straightforward path. The topics in this issue of the ILAR Journal provide assessments of immune-relevant animal models used in oncology, hematopoietic-, CAR-T cell- and xenotransplantation, adjuvants and infectious diseases, and immune privileged inflammation that are providing key insights into unmet human clinical needs.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/31553432/