Peer-reviewed veterinary case report
Intussusception and surgery in dogs after blood cell transplant
By Yunusov, Murad Y et al.·Published in Comparative medicine·2007·Clinical Research Division, United States·View original on PubMed →
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Original publication title: Intussusception in canine recipients of hematopoietic cell grafts and surgical correction.
- Species:
- dog
Plain-English summary
A group of dogs that had received stem cell transplants developed a serious condition called intussusception, where part of the intestine folds into itself, causing blockages. Out of 325 dogs studied, 16 were diagnosed with this issue. Nine of these dogs underwent surgery to remove the affected part of the intestine, and six of them recovered well, while the other seven were treated without surgery but did not improve. The study found that surgery can be safely performed even after a stem cell transplant, and it effectively resolved the problem without recurrence in the dogs that had the procedure.
People also search for: dog intussusception symptoms · stem cell transplant dog recovery · dog surgery for intestinal blockage
Abstract
Intussusception is a common complication after canine hematopoietic cell transplantation (HCT). The present study was undertaken to evaluate predisposing factors of intussusception and to test whether intussusception can be managed surgically during the period immediately after HCT. We determined the incidence of intussusception after HCT was performed in 325 canine recipients (autologous, n = 43; allogeneic, n = 282) during the interval from January 2002 to May 2005. Intussusception was diagnosed in 16 of 325 dogs (4.9%). Intussusception was not significantly associated with the dose of irradiation, source of hematopoietic graft, use of immunosuppressive agents, gender, or age at transplant. A group of 9 of the affected dogs underwent small-bowel resection after diagnosis, and 7 were managed without surgical intervention. Despite complicating factors such as gastrointestinal toxicity and low neutrophil and platelet counts induced by the marrow conditioning regimen and the use of immunosuppressive agents, successful surgical management of intussusception was achieved in 6 of 9 dogs, as compared with successful management of 0 of 7 without surgery. Intussusception did not recur after surgical intervention in any dog. Recent HCT and post-transplant immunosuppressive therapy are not absolute contraindications to surgical intervention for intussusception in canine recipients of HCT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17605344/