Peer-reviewed veterinary case report
Kidney-protective Lactobacillus treats for cats with chronic kidney
By Ching-Wen Tsai et al.·Published in Animals·2024·Department of Animal Science and Technology, National Taiwan University, Taipei 106037, Taiwan, CH·View original on DOAJ →
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Original publication title: Investigating the Efficacy of Kidney-Protective <i>Lactobacillus</i> Mixture-Containing Pet Treats in Feline Chronic Kidney Disease and Its Possible Mechanism
- Species:
- cat
Plain-English summary
A group of cats with chronic kidney disease (CKD) were given special probiotic treats containing a mixture of Lactobacillus for eight weeks to see if it would help their condition. The results showed that the levels of creatinine, a waste product that indicates kidney function, either decreased or stayed the same in all the cats. Additionally, the cats' quality of life improved during the treatment period. This suggests that these probiotic treats could be a helpful addition to the diet of cats suffering from CKD, potentially supporting their kidney health.
People also search for: cat chronic kidney disease treatment · probiotics for cats with kidney disease · improving cat kidney function
Abstract
Microbiota-based strategies are a novel auxiliary therapeutic and preventative way of moderating chronic kidney disease (CKD). <i>Lactobacillus</i> mixture (Lm) was previously demonstrated to exert a renal-protective function in the CKD mice model. The efficacy of probiotics in pet foods is a relatively new area of study, and thus verifying the potential health benefits is necessary. This study evaluated the efficacy of Lm treats in feline CKD and elucidated the mechanisms underlying host-microbe interactions. CKD cats (2 and 3 stages) were administrated probiotic pet treats daily (10 g) for 8 weeks. The results demonstrated that during the eight weeks of Lm administration, creatinine was reduced or maintained in all cats with CKD. Similarly, gut-derived uremic toxin (GDUT), indoxyl sulfate (IS), were potential clinical significance in IS after Lm treatment (confidence intervals = 90%). The life quality of the cats also improved. Feline gut microbiome data, metabolic functional pathway, and renal function indicator analyses revealed the possible mechanisms involved in modulating CKD feline microbial composition. Further regulation of the microbial functions in amino acid metabolism after Lm administration contributed to downregulating deleterious GDUTs. The current study provides potential adjuvant therapeutic insights into probiotic pet foods or treats for pets with CKD.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3390/ani14040630