Peer-reviewed veterinary case report
Kidney-protective probiotic treats for cats with chronic kidney
By Tsai, Ching-Wen et al.·Published in Animals·2024·Department of Animal Science and Technology, National Taiwan University, Taipei 106037, Taiwan·View original on Crossref →
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Original publication title: Investigating the Efficacy of Kidney-Protective Lactobacillus Mixture-Containing Pet Treats in Feline Chronic Kidney Disease and Its Possible Mechanism
- Species:
- cat
Plain-English summary
A group of cats with chronic kidney disease (CKD) were given special probiotic treats containing a Lactobacillus mixture for eight weeks to see if it would help their condition. The results showed that the cats had lower levels of creatinine, a waste product that indicates kidney function, and their overall quality of life improved. This suggests that these probiotic treats could be beneficial for cats with CKD by helping to manage their kidney health and gut bacteria.
People also search for: cat chronic kidney disease treatment · probiotics for cats with kidney disease · improving cat kidney function with diet
Abstract
Microbiota-based strategies are a novel auxiliary therapeutic and preventative way of moderating chronic kidney disease (CKD). Lactobacillus mixture (Lm) was previously demonstrated to exert a renal-protective function in the CKD mice model. The efficacy of probiotics in pet foods is a relatively new area of study, and thus verifying the potential health benefits is necessary. This study evaluated the efficacy of Lm treats in feline CKD and elucidated the mechanisms underlying host-microbe interactions. CKD cats (2 and 3 stages) were administrated probiotic pet treats daily (10 g) for 8 weeks. The results demonstrated that during the eight weeks of Lm administration, creatinine was reduced or maintained in all cats with CKD. Similarly, gut-derived uremic toxin (GDUT), indoxyl sulfate (IS), were potential clinical significance in IS after Lm treatment (confidence intervals = 90%). The life quality of the cats also improved. Feline gut microbiome data, metabolic functional pathway, and renal function indicator analyses revealed the possible mechanisms involved in modulating CKD feline microbial composition. Further regulation of the microbial functions in amino acid metabolism after Lm administration contributed to downregulating deleterious GDUTs. The current study provides potential adjuvant therapeutic insights into probiotic pet foods or treats for pets with CKD.
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Search related cases →Original publication on Crossref: https://doi.org/10.3390/ani14040630