Peer-reviewed veterinary case report
Canine parvovirus outbreak in Alaska dogs studied with new gene
By Parker, Jayme et al.·Published in Scientific Reports·2017·View original on Crossref →
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Original publication title: Investigation of a Canine Parvovirus Outbreak using Next Generation Sequencing
- Species:
- dog
Plain-English summary
A group of dogs in Alaska experienced a serious outbreak of canine parvovirus (CPV), showing symptoms like vomiting and diarrhea. Researchers tested samples from twelve affected dogs and found that all had the virus, indicating a significant health risk in the area, particularly among unvaccinated or under-vaccinated dogs. The study revealed that the outbreak was caused by known strains of the virus, which could still be managed with existing vaccines. This highlights the importance of keeping dogs up to date on their vaccinations to prevent such outbreaks.
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Abstract
AbstractCanine parvovirus (CPV) outbreaks can have a devastating effect in communities with dense dog populations. The interior region of Alaska experienced a CPV outbreak in the winter of 2016 leading to the further investigation of the virus due to reports of increased morbidity and mortality occurring at dog mushing kennels in the area. Twelve rectal-swab specimens from dogs displaying clinical signs consistent with parvoviral-associated disease were processed using next-generation sequencing (NGS) methodologies by targeting RNA transcripts, and therefore detecting only replicating virus. All twelve specimens demonstrated the presence of the CPV transcriptome, with read depths ranging from 2.2X – 12,381X, genome coverage ranging from 44.8–96.5%, and representation of CPV sequencing reads to those of the metagenome background ranging from 0.0015–6.7%. Using the data generated by NGS, the presence of newly evolved, yet known, strains of both CPV-2a and CPV-2b were identified and grouped geographically. Deep-sequencing data provided additional diagnostic information in terms of investigating novel CPV in this outbreak. NGS data in addition to limited serological data provided strong diagnostic evidence that this outbreak most likely arose from unvaccinated or under-vaccinated canines, not from a novel CPV strain incapable of being neutralized by current vaccination efforts.
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Search related cases →Original publication on Crossref: https://doi.org/10.1038/s41598-017-10254-9