Peer-reviewed veterinary case report
Radioiodine dosing methods for treating cat hyperthyroidism
By Morré, Wendy A et al.·Published in Journal of veterinary internal medicine·2018·Department of Small Animal Clinical Sciences·View original on PubMed →
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Original publication title: Investigation of a novel variable dosing protocol for radioiodine treatment of feline hyperthyroidism.
- Species:
- cat
Plain-English summary
A group of hyperthyroid cats were treated with either a variable dose of radioiodine based on their thyroid size and uptake or a standard fixed dose. After six months, about 61% of cats receiving the fixed dose were successfully treated, while 58% of those on the variable dose also became normal. There was no significant difference in the treatment outcomes between the two methods. This means that both dosing strategies were effective in managing feline hyperthyroidism, but the variable dosing did not provide any additional benefits.
People also search for: cat hyperthyroidism treatment · radioiodine for cats · feline thyroid treatment options
Abstract
BACKGROUND: Radioiodine is the treatment of choice for hyperthyroidism in cats. The ideal method of dose determination of radioiodine remains controversial. OBJECTIVE: To compare a method of radioiodine dose determination that utilized thyroid scintigraphy with a standard fixed dose for treatment of hyperthyroidism. ANIMALS: Fifty-seven and 23 client-owned hyperthyroid cats in the variable and fixed dose groups, respectively. METHODS: Cats with a percent dose uptake usingTc-pertechnetate uptake on thyroid scintigraphy <5%, 5%-10%, and >10% were to receive 3, 3.5, or 4.5 millicuries (mCi) of radioiodine, respectively, administered SC. Radioiodine dose was adjusted according to thyroid gland size as determined by the thyroid:salivary size ratio and categorized as <5:1, 5-10:1, and >10:1. If the thyroid size fell into a higher dosing category than the percent dose uptake, the dose was increased accordingly. Cats in the fixed dose group received 4.5 mCi. Six months after treatment, cats were determined to be euthyroid, hypothyroid, or hyperthyroid based on serum thyroxine and thyroid stimulating hormone concentrations. RESULTS: No difference in outcome was found between the variable and fixed dose treatment groups. Euthyroidism, hypothyroidism, and persistent hyperthyroidism developed in 61, 30, and 9% of cats in the fixed dose group compared to 58, 26, and 16%, respectively, in the variable dose group. CONCLUSIONS: A variable dosing method of radioiodine based on percent dose uptake primarily and thyroid gland size secondarily did not improve outcome compared to a standard fixed dose method.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30328158/