Peer-reviewed veterinary case report
Neutrophil involvement in acute dog atopic dermatitis skin
By Tamamoto-Mochizuki, Chie & Mishra, Santosh K.·Published in Frontiers in Allergy·2025·View original on Crossref →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Investigation of neutrophil infiltration in the acute canine atopic dermatitis model
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin condition causing chronic itching and inflammation) were exposed to house dust mites to study how certain immune cells, called neutrophils, reacted over time. Skin samples were taken at different intervals after exposure, showing that neutrophils started to appear in the skin between 24 and 96 hours after the allergen challenge. The results indicated a significant increase in neutrophils at 48 hours, suggesting they play an important role in the early stages of this skin condition. Understanding this could help improve treatments for dogs suffering from atopic dermatitis.
People also search for: dog itchy skin treatment · neutrophils in dog skin problems · house dust mite allergy in dogs
Abstract
Atopic dermatitis (AD) is an inflammatory skin condition associated with chronic itch and inflammation in both humans and animals. While this disease depends upon various immune cell types, the precise role and kinetics of neutrophils remain elusive, particularly in relevant large-animal models. Given a recent report suggesting the involvement of neutrophils in a mouse model, we aimed to characterize the temporal presence and infiltration of these cells in a canine model of house dust mite (HDM)-induced AD. AD was induced in canines via HDM exposure, and skin biopsies were analyzed over a time course (0–96 h) using standard H&E staining and specific immunofluorescent (IF) staining for canine neutrophils. Our results showed general cellular infiltration with the H&E method, while IF further confirmed detectable neutrophil immunoreactivity starting between 24 and 96 h post-challenge in atopic skin. Quantitation demonstrated a significant increase in neutrophil infiltration (cells/mm 2 ) in atopic skin at 48 h following HDM exposure compared to baseline ( p = 0.041). Collectively, our data confirms time-dependent infiltration of neutrophils into the skin of the canine AD model following allergen challenge, supporting the hypothesis that this previously overlooked immune cell may play a role in the acute phase of AD pathogenesis and sensitization.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on Crossref: https://doi.org/10.3389/falgy.2025.1716716