Peer-reviewed veterinary case report
Investigation of tumour-infiltrating immune cells as a prognostic factor in feline oral squamous cell carcinoma.
- Journal:
- Journal of comparative pathology
- Year:
- 2025
- Authors:
- Mihardi, Arief P et al.
- Affiliation:
- Joint Graduate School of Veterinary Medicine · Japan
- Species:
- cat
Abstract
This study aimed to evaluate the prognostic significance of tumour-infiltrating immune cells in feline oral squamous cell carcinoma (OSCC). Immunohistochemistry was used to quantify tumour-infiltrating immune cells in 20 feline OSCC samples. CD3T, CD8T, Foxp3regulatory T and CD20B cells and CD204macrophages were assessed in both the tumour and stroma areas. Immune cell infiltration was more prominent in the stroma area, particularly for CD20B cells. High CD3T-cell and CD20B-cell densities were negatively correlated with survival outcomes. Moreover, based on infiltration level, low densities of CD3T cell infiltration were significantly associated with longer overall survival times. Likewise, low densities of CD8T cells were linked with significantly longer progression-free intervals.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/41539916/