Peer-reviewed veterinary case report
How allergen exposure affects skin infections in dogs
By Marsella, Rosanna·Published in Veterinary Sciences·2021·Department of Small Animal Clinical Sciences, University of Florida, Gainesville, FL 32608, USA, United States·View original on Crossref →
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Original publication title: Investigation on the Effect of Dose, Frequency and Duration of Allergen Exposure on Development of Staphylococcal Infections in a Chronic Model of Canine Atopic Dermatitis
- Species:
- dog
Plain-English summary
A group of dogs with chronic skin allergies (canine atopic dermatitis) were studied to see how different levels and durations of allergen exposure affected their risk of developing skin infections caused by Staphylococcus bacteria. The results showed that dogs exposed to low doses of allergens daily for an extended period were more likely to develop infections compared to those receiving higher doses less frequently. Specifically, after three months of exposure, 6 out of 9 dogs developed infections, while none developed infections after just one week of exposure. This suggests that managing allergen exposure is crucial in preventing skin infections in dogs with allergies.
People also search for: dog skin allergies treatment · Staphylococcus infection in dogs · canine atopic dermatitis management
Abstract
Canine atopic dermatitis (CAD) is chronic and frequently complicated by Staphylococcal infections. Understanding the role of allergen dose, frequency and duration of exposure in triggering infections requires a model. Most models elicit acute inflammation and do not mimic real-life disease. Here we describe the effects of allergen exposures on development of infections in a model of chronic CAD. Diagnosis of pyoderma was based on clinical signs and consistent cytology. Study 1 evaluated the role of duration of exposure keeping the daily dose constant (25 mg/day). The one-week protocol involved three exposures, 3 days in a row. The one-month protocol involved twice-weekly challenges for 4 weeks. The three-month protocol involved twice-weekly challenges for 12 weeks. Study 2 evaluated different daily doses while keeping constant the total weekly dose (25 mg) and duration (3 weeks). Low-dose used 5 mg/day for 5 days, each week. High-dose used 12.5 mg/day twice-weekly. In Study 1, the longer the exposure, the more dogs developed pyoderma (6/9 in the three-month study, 2/9 in the one-month and 0 in the one-week). In Study 2, low-dose daily exposure caused more infections (5/8) than high-dose infrequent exposure (0/8). It is concluded that low-grade, daily exposure for a long time is most relevant for development of staphylococcal infections.
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Search related cases →Original publication on Crossref: https://doi.org/10.3390/vetsci9010008