Peer-reviewed veterinary case report
Severe mouth and skin warts in Shar Pei dog linked to oral
By Sundberg, J P et al.·Published in Veterinary pathology·1994·Jackson Laboratory·View original on PubMed →
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Original publication title: Involvement of canine oral papillomavirus in generalized oral and cutaneous verrucosis in a Chinese Shar Pei dog.
- Species:
- dog
Plain-English summary
An 8-month-old female Chinese Shar Pei was brought in with severe warts in her mouth and on her skin, which had spread across her body. The dog had been given corticosteroids, which may have weakened her immune system and allowed the warts to develop. After stopping the steroids and treating her with a mitocide, antibiotics, and a special vaccine made from her own immune cells, the warts and skin issues improved significantly. This case highlights how certain medications can affect a dog's immune response and lead to skin problems.
People also search for: dog warts treatment · Chinese Shar Pei skin problems · corticosteroids side effects in dogs
Abstract
Severe papillomatosis developed in the oral cavity and spread throughout the haired skin of the trunk and limbs of an 8-month-old female Chinese Shar Pei dog. The dog had received corticosteroids prior to referral, which was associated with the onset of demodecosis and papillomatosis. Papillomavirus structural antigens were detected in biopsies by immunohistochemistry using a panel of monoclonal and polyclonal antibodies. An 8.2-kilobase papillomavirus-specific DNA molecule was detected in the cutaneous lesions by high stringency Southern blot hybridization using a cloned canine oral papillomavirus DNA probe. Restriction enzyme analysis revealed that the virus in the cutaneous lesions was identical to the canine oral papillomavirus. Discontinuation of the steroids combined with the use of a mitocide, antibiotics, and an autogenous vaccine resolved the demodecosis and papillomatosis. This case report suggests that corticosteroid-induced immunosuppression can expand the tissue tropism of papillomaviruses.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8203080/