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Peer-reviewed veterinary case report

How changing diet can fix high calcium in cats with kidney disease

By Ehrlich, Margot R et al.·Published in Journal of feline medicine and surgery·2024·Department of Veterinary Clinical Sciences, United States·View original on PubMed

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Original publication title: Ionized hypercalcemia can resolve with nutritional modification in cats with idiopathic hypercalcemia or chronic kidney disease.

Species:
cat

Plain-English summary

A group of cats with high levels of calcium in their blood (ionized hypercalcemia) were switched to special diets that had lower calcium content and a better balance of calcium to phosphorus. Most of the cats showed improvement, with nine out of ten having lower calcium levels after about nine weeks. Six of those cats returned to normal calcium levels, while two others who were given chia seeds also normalized their calcium levels later on. This suggests that adjusting a cat's diet can be an effective way to manage high calcium levels, especially in cases related to kidney disease or unknown causes.

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Abstract

CASE SERIES SUMMARY: Cats with ionized hypercalcemia that were fed diets with either more than 200 mg calcium per 100 kilocalories (kcal), a calcium:phosphorus (Ca:P) ratio greater than 1.4:1 or both, based on diet history, were included in this case series. Ionized hypercalcemia was documented at least twice in all cats before enrollment. Cats were referred for evaluation of ionized hypercalcemia (n = 5) or were incidentally found to have ionized hypercalcemia (n = 5). After medical workups, cats were diagnosed with either idiopathic hypercalcemia (IHC; n = 7) or chronic kidney disease (n = 3). Cats receiving medications to treat IHC (eg, alendronate, corticosteroids) were excluded. Nutritional recommendations were made to transition the cats to diets with less thn 200 mg calcium per 100 kcal and a Ca:P ratio less than 1.4:1. Ionized calcium (iCa) concentrations were rechecked in all cats, with a median recheck time of 9 weeks (range 3-20). Of the 10 cats, nine (90%) had a decrease in iCa. Of the 10 cats, six (60%) became normocalcemic after the diet change, three (30%) had a partial response and one (10%) did not respond. Of the four cats that did not achieve normocalcemia with a change in diet, two (50%) received chia seeds (1-2 g per day), and at the next recheck, both cats' iCa concentrations had normalized. Three cats had a long-term follow-up. Ionized normocalcemia was maintained for at least two consecutive follow-up visits over a median follow-up period of 33 weeks (range 12-34). RELEVANCE AND NOVEL INFORMATION: Dietary calcium concentrations and the dietary Ca:P ratio appear to be important variables in considering nutritional approaches for hypercalcemic cats.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38415620/