Peer-reviewed veterinary case report
Eye tumor with oncocytic change in a Pembroke Welsh Corgi dog
By Okawauchi, Mitsuteru et al.·Published in The Journal of veterinary medical science·2016·Sanritsu Zelkova Veterinary Laboratory, Japan·View original on PubMed →
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Original publication title: Iridociliary adenocarcinoma with oncocytic change in a dog.
- Species:
- dog
Plain-English summary
A spayed female Pembroke Welsh Corgi was found to have an unusual growth in her left eye, which was causing concern. After surgery to remove the affected eyeball, tests revealed that the mass was a type of cancer called iridociliary adenocarcinoma, which had some specific changes in the cancer cells. These changes were linked to the cells' energy-producing structures, suggesting they were behaving abnormally. Unfortunately, the prognosis for this type of cancer can vary, and further treatment options would need to be discussed with a veterinarian.
People also search for: dog eye cancer treatment · Pembroke Welsh Corgi eye problems · iridociliary adenocarcinoma in dogs
Abstract
An intraocular mass lesion was found in the left eyeball in a spayed female Pembroke Welsh Corgi dog. The surgically resected left eyeball was pathologically examined. Histologically, the mass lesion consisted of proliferation of the atypical cuboidal or columnar epithelial cells, arranging in papillary, tubular or solid form. In addition, some neoplastic cells showed oncocytic change characterized as large oval cells with numerous eosinophilic intracytoplasmic granules. Cytoplasm of the oncocytic cells showed dark blue granules by phosphotungstic acid-hematoxylin stain. Immunohistochemically, the oncocytic cells were intensely positive for cytochrome C. Based on these findings, the ocular mass was diagnosed as iridociliary adenocarcinoma with oncocytic change. The findings indicate that the oncocytic changes of the neoplastic epithelial cells might be caused by mitochondrial accumulation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26822120/