Iron Acquisition Strategies of.

Abstract

The hemorrhagic septicemic disease vibriosis caused byshows noticeable similarities to invasive septicemia in humans, and in this case, the-host system has the potential to serve as a model for understanding native eukaryotic host-pathogen interactions. Iron acquisition, as a fierce battle occurring between pathogenicand the fish host, is a pivotal step for virulence. In this article, advances in defining the roles of iron uptake pathways in growth and virulence ofhave been summarized, divided into five aspects, including siderophore biosynthesis and secretion, iron uptake, iron release, and regulation of iron uptake. Understanding the molecular mechanisms of iron acquisition will have important implications for the pathogenicity of this organism.