Is there any effect of montelukast on prevention of myringosclerosis after myringotomy in a rat model?

Abstract

OBJECTIVES: In this study, our aim was to identify the possible effects of montelukast sodium (ML) on the prevention of experimentally induced myringosclerosis. MATERIALS AND METHODS: Twenty-eight female Wistar albino rats were used and they were divided into four groups randomly. Tympanic membranes (TM) of all animals were perforated and then group 1 received no treatment (control group), group 2 was treated with a topical saline solution, group 3 received topically ML and group 4 received orally ML. On the 15th day, all animals were euthanized. Tympanic membranes were evaluated otomicroscopically and histopathologically. RESULTS: The histopathological findings, compared against a control and saline groups, showed the topically and orally ML groups had statistically significant differences of degree of myringosclerosis (p&#x2009;<&#x2009;0.002) and median thickness of the TMs (p&#x2009;<&#x2009;0.001). Suppression of inflammation was statistically significant only in the oral ML treatment group (p&#x2009;<&#x2009;0.002). CONCLUSION: Oral and topically administration of ML reduced myringosclerosis formation in myringotomies rats.