Peer-reviewed veterinary case report
Isocitrate lyase (AceA) is required for Salmonella persistence but not for acute lethal infection in mice.
- Journal:
- Infection and immunity
- Year:
- 2005
- Authors:
- Fang, Ferric C et al.
- Affiliation:
- Department of Laboratory Medicine · United States
- Species:
- rodent
Abstract
Isocitrate lyase is required for fatty acid utilization via the glyoxylate shunt. Although isocitrate lyase is essential for Salmonella persistence during chronic infection, it is dispensable for acute lethal infection in mice. Substrate availability in the phagosome appears to evolve over time, with increasing fatty acid dependence during chronic infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15784602/