Peer-reviewed veterinary case report
Chihuahua puppy with low growth hormone and repeated low blood sugar
By Iio, Aki et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2020·Department of Veterinary Clinical Pathobiology, Japan·View original on PubMed →
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Original publication title: Isolated growth hormone deficiency in a Chihuahua with amutation.
- Species:
- dog
Plain-English summary
A 6-month-old female Chihuahua was brought to the vet because she was having repeated episodes of low blood sugar and collapsing. During the exam, the vet noticed she was smaller than normal for her age, still had her puppy fur, and had some baby teeth that hadn’t fallen out. Blood tests showed low blood sugar and other irregularities, but other tests like X-rays and ultrasounds looked normal. Further testing revealed she had a growth hormone deficiency, which was confirmed by a special stimulation test. Unfortunately, this condition is linked to genetic mutations, and while treatment options may be limited, managing her diet and monitoring her blood sugar levels will be important.
People also search for: Chihuahua low blood sugar treatment · puppy growth hormone deficiency · why is my dog collapsing
Abstract
A 6-mo-old female Chihuahua was presented with recurrent episodes of hypoglycemia and collapse. Physical examination revealed proportionate dwarfism, retained puppy hair coat, retained deciduous teeth, and open fontanelles. Routine blood tests revealed hypoglycemia, thrombocytosis, hypoproteinemia, and elevated alkaline phosphatase activity. The urinalysis, radiographs, and ultrasonographs were unremarkable. Endocrine testing revealed that insulin-like growth factor 1 was below the detection limit; concentrations of total thyroxine, baseline cortisol, and cortisol stimulated by tetracosactide acetate were within their reference intervals. The pituitary gland showed no organic abnormalities on magnetic resonance imaging. For definitive diagnosis, we conducted the stimulation test for growth hormone (GH) release and diagnosed isolated GH deficiency. Genetic investigation revealed that the present case had 4 point mutations in intronic regions and a 6-bp deletion in exon 5 of. The bioinformatics tool PROVEAN algorithm predicted that the deletion in exon 5 could be deleterious to the function of.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32646299/