Peer-reviewed veterinary case report
Canine parvovirus strains in Chinese pets and effects in beagles
By Chen, M R et al.·Published in Polish journal of veterinary sciences·2019·Institute of Animal Sciences, China·View original on PubMed →
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Original publication title: Isolation and sequence analysis of the complete VP2 gene of canine parvovirus from Chinese domestic pets and determination of the pathogenesis of these circulating strains in beagles.
- Species:
- dog
Plain-English summary
A group of beagles was studied after showing signs of severe illness due to canine parvovirus (CPV), which causes vomiting and diarrhea. Researchers found that a new strain of CPV, known as CPV-2a, was the most common among infected dogs in Beijing. Unfortunately, some of the beagles that were experimentally infected with this strain died, and tests showed the virus affected multiple organs, including the liver and intestines. This highlights the seriousness of CPV infections and the need for ongoing monitoring of the virus's evolution in pets.
People also search for: dog vomiting diarrhea parvovirus · beagle CPV treatment · canine parvovirus symptoms
Abstract
Canine parvovirus (CPV) causes acute gastroenteritis in domestic dogs, cats, and several wild carnivore species. In this study, the full-length VP2 gene of 36 CPV isolates from dogs and cats infected between 2016 and 2017 in Beijing was sequenced and analyzed. The results showed that, in dogs, the new CPV-2a strain was the predominant variant (n = 18; 50%), followed by the new CPV-2b (n = 6; 16.7%) and CPV-2c (n = 3; 8.3%) strains, whereas, among cats, the predominant strain was still CPV-2 (n = 9; 25%). One new CPV-2a strain, 20170320-BJ-11, and two CPV-2c strains, 20160810-BJ-81 and 20170322-BJ-26, were isolated and used to perform experimental infections. Multiple organs of beagles that died tested PCR positive for CPV, and characteristic histopathological lesions were observed in organs, including the liver, spleen, lungs, kidneys, small intestines, and lymph nodes. Experimental infections showed that the isolates from the epidemic caused high morbidity in beagles, indicating their virulence in animals and suggesting the need to further monitor evolution of CPV in China.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31269343/