Peer-reviewed veterinary case report
Isolation of a highly cytopathic lentivirus from a nondomestic cat.
- Journal:
- Journal of virology
- Year:
- 1995
- Authors:
- Barr, M C et al.
- Affiliation:
- Department of Microbiology and Immunology · United States
- Species:
- cat
Plain-English summary
Researchers found a new type of virus called FIV-Oma in a Pallas' cat, which is a wild cat species. This virus behaves differently from a similar virus found in domestic cats, as it causes more severe damage to certain cells in the lab. While the virus shares some similarities with the domestic cat virus, they are not identical, and the genetic makeup shows that FIV-Oma is related to other viruses found in different animals, including humans and sheep. This study helps us understand the differences between viruses affecting wild and domestic cats.
Abstract
A feline immunodeficiency virus-like virus (FIV-Oma) isolated from a Pallas' cat (Otocolobus manul) is highly cytopathic in CrFK cells, in contrast to the chronic, noncytolytic infection established by an FIV isolate from a domestic cat (FIV-Fca). The virions have typical lentivirus morphology, density, and magnesium-dependent reverse transcriptase activity. The major core protein is antigenically cross-reactive with that of FIV-Fca; however, FIV-Oma transcripts do not cross-hybridize with FIV-Fca. A conserved region of the FIV-Oma pol gene has 76 to 80% nucleic acid identify with the corresponding pol regions of other feline lentiviruses and 64 to 69% identity with those of human, ovine, and equine lentiviruses.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/7474172/