Peer-reviewed veterinary case report
Isolation of a multidrug-resistantpathotype Stx2:Cnf1:Cnf2:Eae as a potential cause of hemorrhagic diarrhea and secondary septicemia in a dog.
- Journal:
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
- Year:
- 2022
- Authors:
- Jonker, Annelize et al.
- Affiliation:
- Faculty of Veterinary Science
- Species:
- dog
Plain-English summary
A dog developed vomiting and severe diarrhea with blood after having surgery and unfortunately passed away despite receiving treatment. A thorough examination after the dog's death showed inflammation in the stomach and intestines. Researchers found a type of bacteria in the dog's organs that was resistant to multiple antibiotics and had genes that could make it very harmful. This type of bacteria can be shared between pets and their owners, which raises concerns about its potential impact on both animals and humans. Sadly, the treatment did not save the dog.
Abstract
is a member of the familyand is a commensal in the intestine of many animals as well as humans. Most strains are of low virulence. A dog developed vomiting and hemorrhagic diarrhea after surgery and died despite treatment. Postmortem examination revealed hemorrhagic gastroenteritis and colitis. A multidrug-resistant, with virulence factors Shiga-toxin-producing gene, stx2,gene, and cytotoxic necrotic factors CNF-1 and CNF-2, was isolated from internal organs.can easily acquire new genes for virulence factors and antimicrobial resistance as demonstrated by this isolate with characteristics of both enterohemorrhagicand necrotoxigenic. In addition, the isolate was resistant to all beta-lactam antibiotics tested, as well as to enrofloxacin by a disk diffusion methodology. Broth-based minimum inhibitory concentration analysis confirmed resistance to amoxicillin (>32 μg/mL), enrofloxacin (>32 μg/mL), fosfomycin (>128 μg/mL), and neomycin (>32 μg/mL). The discovery of such strains is a cause for concern given thatcan be shared by companion animals and their human owners.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/35075964/