Peer-reviewed veterinary case report
Isolation of Methyl Troposulfenin from Phaeobacter inhibens.
- Journal:
- Journal of natural products
- Year:
- 2019
- Authors:
- Phippen, Christopher B W et al.
- Affiliation:
- Department of Biotechnology and Biomedicine
Abstract
An S-methylated analogue of tropodithietic acid (TDA, 1), methyl troposulfenin (2), was isolated from the marine alphaproteobacterium Phaeobacter inhibens. The structure was elucidated by NMR and HRMS. Its inhibitory effect against the fish pathogen Vibrio anguillarum was 4-fold to 100-fold lower than that of the known antibacterial compound TDA. Methyl troposulfenin lacks the acidic proton of TDA, indicating that the methylation turns the potent antibacterial TDA into an inactive compound, and thereby, this analysis supports the proposed mode of action of TDA.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30978024/