Peer-reviewed veterinary case report
Autoantibody types in dogs with autoimmune blistering skin diseases
By Favrot, Claude et al.·Published in Veterinary dermatology·2003·Université, Canada·View original on PubMed →
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Original publication title: Isotype determination of circulating autoantibodies in canine autoimmune subepidermal blistering dermatoses.
- Species:
- dog
Plain-English summary
A group of dogs with autoimmune skin diseases, specifically bullous pemphigoid, mucous membrane pemphigoid, and epidermolysis bullosa acquisita, were tested for specific autoantibodies in their blood. All dogs had autoantibodies that attacked their skin's basement membrane, which can lead to painful blisters. The most common types found were IgG1 and IgG4, along with some IgE. This study helps veterinarians understand these conditions better and may guide treatment options for affected dogs.
People also search for: dog autoimmune skin disease treatment · bullous pemphigoid in dogs · dog skin blisters causes
Abstract
The three most common canine autoimmune blistering skin diseases (AISBD), bullous pemphigoid (BP), mucous membrane pemphigoid (MMP) and epidermolysis bullosa acquisita (EBA) have recently been separated based on clinical, histological and immunological grounds. The objectives of this study were to determine the isotype profiles of circulating autoantibodies in these dermatoses. Serum was collected from 5 dogs with BP, 15 with MMP and 11 with EBA. All sera were tested using an indirect immunofluorescence method using salt-split canine gingiva as substrate. Anti-basement membrane IgG autoantibodies were detected in all patients. Among the IgG autoantibodies, IgG1 and IgG4 were encountered most frequently, while IgG2 and IgG3 were uncovered in some dogs. IgE autoantibodies were detected more often than IgA or IgM autoantibodies in any of the three entities. The predominance of IgG1, IgG4 and IgE autoantibody isotypes in dogs with AISBD is very similar to the situation found in humans with the homologous diseases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12603682/