Peer-reviewed veterinary case report
Ivermectin poisoning in dogs and what to watch
By Merola, Valentina et al.·Published in Journal of the American Animal Hospital Association·2009·ASPCA Animal Poison Control Center, United States·View original on PubMed →
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Original publication title: Ivermectin toxicosis in dogs: a retrospective study.
- Species:
- dog
Plain-English summary
A dog was brought in showing signs of ivermectin poisoning after accidentally ingesting a dose of the medication. Symptoms can appear even at lower doses than previously thought, especially in certain breeds that may have a genetic defect making them more sensitive to the drug. The veterinarian assessed the dog's condition and provided supportive care, which is crucial in these cases. It's important for pet owners to be aware of the risks associated with ivermectin and to consult their vet if they suspect an overdose.
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Abstract
Ivermectin is a commonly used veterinary drug that may cause serious problems in overdose situations. A retrospective study was completed, which evaluated canine exposures to ivermectin from 1998 to 2005. The cases were evaluated based on ivermectin dosage, clinical signs seen, signalment of the animal involved, and the potential that the animal could have a p-glycoprotein defect. Results showed that clinical signs may be seen in some animals at doses lower than previously reported. Some dogs may have p-glycoprotein defects or other reasons for increased susceptibility to ivermectin toxicosis. The clinician should be aware that clinical signs may develop even at dosages previously thought to be of little risk (e.g., 0.2 to 2.5 mg/kg in breeds historically considered to have normal p-glycoprotein function).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19411645/