Peer-reviewed veterinary case report

Joint deletion of multifunctional MGF505-7R and H240R genes generates a safe and effective African swine fever virus attenuated live vaccine candidate.

Journal:: Virologica Sinica
Year:: 2024
Authors:: Weng, Changjiang et al.
Affiliation:: Harbin Veterinary Research Institute · China

Movement & joints

Abstract

•andare virulence-related genes. • ASFV-ΔΔis attenuated. • The candidate vaccine is safe and protective.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/38697264/

Development of a new effective African swine fever virus vaccine candidate by deletion of the H240R and MGF505-7R genes results in protective immunity against the Eurasia strain.Journal of virology · 2023
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The deletion of the EP402R and MGF505/360 genes attenuates a genotype I/II recombinant ASFV but fails to confer complete protection against homologous or genotype II challenge in pigs.Emerging microbes & infections · 2026