Peer-reviewed veterinary case report
Dog treated with ketoconazole developed temporary low adrenal hormone
By Sullivant, Alyssa M & Lathan, Patty·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2020·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Ketoconazole-induced transient hypoadrenocorticism in a dog.
- Species:
- dog
Plain-English summary
A 6-year-old spayed female mixed breed boxer was brought to the vet because she had a decreased appetite, was drinking and urinating more than usual, and seemed lethargic. These symptoms appeared 9 days after she was treated with ketoconazole for a skin condition. The vet confirmed that the medication caused a temporary adrenal gland issue, so they stopped the ketoconazole and started her on prednisone. Within 48 hours of starting the prednisone, her symptoms improved, and follow-up tests showed her adrenal function had returned to normal.
People also search for: dog decreased appetite after ketoconazole · boxer drinking more water · prednisone for dog lethargy
Abstract
A 6-year-old, spayed female, mixed breed boxer dog was presented for decreased appetite, polyuria and polydipsia, and lethargy 9 days after treatment with ketoconazole forpododermatitis. Ketoconazoleinduced hypoadrenocorticism was confirmed with an adrenocorticotropic hormone (ACTH) stimulation test, and ketoconazole was discontinued. Clinical signs resolved 48 hours after initiation of prednisone, and resolution of glucocorticoid insufficiency was confirmed with a repeat ACTH stimulation test 48 hours after a 10-day course of prednisone. Glucocorticoid insufficiency after administration of a commonly used dermatological dose of ketoconazole has not been previously reported in veterinary medicine but should be considered in patients with adverse effects while receiving ketoconazole. Key clinical message: Iatrogenic hypoadrenocorticism may occur in dogs treated with commonly used dermatological doses of ketoconazole. The disease is likely transient, but steroid supplementation may be required in some patients to resolve clinical signs, especially in the presence of concurrent illness or stress.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32255827/