Peer-reviewed veterinary case report
Ki-67 test helps diagnose and predict dog perianal gland tumors
By Pereira, Rodrigo Storti et al.·Published in BMC veterinary research·2013·College of Veterinary Medicine Araç, Brazil·View original on PubMed →
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Original publication title: Ki-67 labeling in canine perianal glands neoplasms: a novel approach for immunohistological diagnostic and prognostic.
- Species:
- dog
Plain-English summary
A study looked at 42 dogs with tumors in their perianal glands, which are located near the anus. The researchers used a special test called Ki-67 to measure how quickly the tumors were growing. They found that tumors classified as carcinomas (a type of cancer) had a much higher growth rate compared to adenomas and epitheliomas, and these carcinomas were more likely to come back after treatment. This test could help veterinarians better diagnose and predict the behavior of these tumors, especially in cases where the tumors look very different from each other.
People also search for: dog perianal tumor treatment · Ki-67 test for dog cancer · dog anal gland cancer prognosis
Abstract
BACKGROUND: The antibody Ki-67 is a reliable and easy tool to accurately assess the growth fraction of neoplasms in humans and animals, and it has been used to predict the clinical outcome. Therefore, the aim of the present study was to investigate the immunohistochemical expression pattern of Ki-67 in normal and neoplastic perianal glands of dogs to evaluate the possible use of this proliferation marker as an ancillary method of perianal tumor diagnosis. We studied 42 cases of perianal gland neoplasms including adenomas (n = 15), epitheliomas (n = 15), and carcinomas (n = 12). As controls, 13 tissue samples from normal perianal glands were used. A Ki-67 index was established by a computer-assisted image analysis and compared with manual counting. RESULTS: Out of the 42 cases of perianal gland neoplasms, 34 were from males and eight from females. Recurrence was reported in 14 cases, being higher (8/12) in carcinomas. Immunostaining for Ki-67 revealed that the carcinomas showed a higher proliferation rate (9.87%) compared to groups of epitheliomas (2.66%) and adenomas (0.36%). For adenomas and epitheliomas of the perianal glands the computer-assisted counting and the manual counting gave similar results; however, only the computer-assisted image analysis was efficient to predict the perianal gland carcinoma recurrence. CONCLUSION: Since there were significant differences in the number of Ki-67-positive nuclei, this marker proved to be effective in helping the classification of perianal gland neoplasms and to refine the diagnosis criteria, especially in those samples with high variation in morphology/area. Also, higher Ki-67 index is related to recurrence in cases of perianal gland carcinomas. Further, the computer-assisted image analysis proved to be a fast and reliable method to assess the Ki-67 index in perianal gland neoplasms.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23601191/