Peer-reviewed veterinary case report
Ki67 index and outcomes in grade 2 low-grade dog skin mast cell
By Marzia Cino et al.·Published in Veterinary Sciences·2023·Department of Veterinary Medical Sciences, University of Parma, Strada del Taglio 10, 43126 Parma, Italy, CH·View original on DOAJ →
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Original publication title: Ki67 Index in Patnaik Grade 2/Kiupel Low-Grade Canine Cutaneous Mast Cell Tumors with Early Lymph Node Metastasis: A Descriptive Study
- Species:
- dog
Plain-English summary
A group of dogs with low-grade skin tumors called mast cell tumors (MCTs) were treated with surgery to remove the tumors and nearby lymph nodes. None of the 39 dogs experienced local or lymph node relapses, and most (82%) were still alive at the end of the study, with an average survival time of about 893 days. The study found that the Ki67 index, which is sometimes used to predict tumor behavior, did not have a significant impact on the dogs' outcomes. This suggests that dogs with this type of tumor may do well with surgery alone.
People also search for: dog mast cell tumor treatment · low-grade mast cell tumor prognosis · Ki67 index in dogs
Abstract
Several studies evaluating Ki67 in canine cutaneous mast cell tumors (cMCTs) have reported its prognostic value when tumors of all histological grades are included. This study aims to evaluate whether the Ki67 index has a predictive value in a homogeneous cohort of G2/LG cMCTs with HN2 lymph nodes (LNs) and to describe the clinical outcome. The second goal was to explore the correlation between the Ki67 index and MC. The medical databases of three institutions were retrospectively searched for dogs undergoing surgical treatment for cMCT and LN extirpation, with a histological diagnosis of G2/LG with HN2 LNs. Information about histological margins, MC, Ki67 index, local recurrence, nodal relapse, distant metastasis, de novo cMCT occurrence and date and cause of death were included. A total of 39 cases were identified. None of these developed local and nodal relapse or metastatic distant disease. Median MC was 1 (0–2). Median Ki67 index was 3.5 (0.7–14.3). Ki67 and MC were not significantly correlated. At the end of the study, 32 (82%) dogs were alive, 7 (18%) dogs were dead from unrelated causes and 4 (10.2%) dogs were lost to follow-up. The median ST was not reached, and the mean was 893 days (104–2241 days). Considering the strict inclusion criteria, dogs affected by G2/LG with HN2 LNs treated with surgery alone may have a good oncologic outcome; the Ki67 index does not have prognostic impact.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3390/vetsci10070436