Peer-reviewed veterinary case report
Ki67 and KIT staining in Boxer dog skin mast cell tumors
By Fonseca-Alves, Carlos Eduardo et al.·Published in Research in veterinary science·2015·Veterinary Clinic Department, Brazil·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Ki67/KIT double immunohistochemical staining in cutaneous mast cell tumors from Boxer dogs.
- Species:
- dog
Plain-English summary
A group of Boxer dogs with skin tumors called mast cell tumors (MCTs) were studied to see how certain cell markers could help predict their behavior and survival. Researchers found that about 29% of the tumors showed a specific combination of markers (Ki67 and KIT), which was linked to a shorter survival time. Dogs with tumors that tested negative for Ki67 but positive for KIT lived longer than those with both markers present. This information could help veterinarians better understand the prognosis for dogs with MCTs and tailor treatment plans accordingly.
People also search for: Boxer dog mast cell tumor prognosis · dog skin tumor treatment · mast cell tumor survival rate in dogs
Abstract
Cutaneous mast cell tumors (MCTs) are among the most frequent malignant tumors in dogs and Boxer breed dogs have a higher incidence of this disease. Ki67 staining and KIT staining are widely used to predict natural behavior in canine MCT but no previous study has evaluated double staining of these proteins as a prognostic factor. Based on biological behavior predictors in canine MCT, the purpose of this study was to determine the Ki67 proliferative index in KIT positive cells using double stain immunohistochemistry technique. Sixty-nine MCTs from Boxer dogs were selected and a tissue microarray was constructed for the double stained immunohistochemistry. Double positivity (Ki67(+)/KIT(+)) was observed in 20/69 (29%) MCT, with a mean of 9.06 double positive cells per tissue core (range 0.48%-43.97%) and Ki67(-)/KIT(+) animals had a longer survival time than Ki67(+)/KIT(+) animals (p=0.03).
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26412531/