Peer-reviewed veterinary case report
Kidney injury associated with telavancin dosing regimen in an animal model.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2015
- Authors:
- Tam, Vincent H et al.
- Affiliation:
- University of Houston · United States
- Species:
- rodent
Abstract
The elevation of serum creatinine levels is a concern with telavancin therapy. We examined the onset of kidney injury associated with telavancin in an animal model. Urine samples were collected at baseline and daily to determine the concentrations of kidney injury molecule 1 (KIM-1), a marker for early kidney injury. When a clinically relevant exposure of telavancin was given daily to rats, some differences in kidney injury were attributed to the dosing regimen. Further investigations of alternative telavancin dosing regimens are warranted.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25712358/