Peer-reviewed veterinary case report
Kidney injury molecule-1 and urinary enzyme levels in cats
By Xavier Júnior, F A F et al.·Published in The Journal of small animal practice·2022·Faculty of Veterinary, Brazil·View original on PubMed →
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Original publication title: Kidney injury molecule-1 and urinary gamma-glutamyl transferase as biomarkers of acute kidney injury in cats.
- Species:
- cat
Plain-English summary
A group of 20 cats with urethral obstruction were tested for kidney health markers, showing higher levels of certain substances in their urine compared to healthy cats. These cats had elevated serum creatinine levels and a specific enzyme (gamma-glutamyl transferase) that indicated potential kidney injury. After treatment to relieve the obstruction, their kidney function improved over time, with serum creatinine levels decreasing and urine creatinine levels increasing. This suggests that monitoring these markers can help assess kidney damage in cats with urinary blockages.
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Abstract
OBJECTIVES: To evaluate the concentration of kidney injury molecule-1 and activity of urinary gamma-glutamyl transferase in cats with urethral obstruction and healthy cats. MATERIALS AND METHODS: Blood and urine samples were collected from a group of 15 healthy cats (control group) and a group of 20 cats with urethral obstruction at presentation, and 24 hours and 7 days after unblocking the obstruction. The serum creatinine, urinary creatinine and urinary gamma-glutamyl transferase were measured by spectrophotometry and kidney injury molecule-1 by the sandwich enzyme-linked immunosorbent assay. RESULTS: On presentation, cats with obstruction had serum creatinine concentration and urinary gamma-glutamyl transferase index higher than healthy cats (mean difference 544 μmol/L, 95% confidence intervals 222 to 865 μmol/L, and 0.0022 U/μmol-uCre, 0.00043 to 0.0039 U/μmol-uCre, respectively), urine creatinine concentration lower (mean difference 25,624 µmol/L, 17,329 to 33,919 µmol/L), and no significant difference in the kidney injury molecule-1/urinary creatinine ratio (mean difference 13 pg/μmol-uCre, -33 to 59 pg/μmol-uCre). In the group of cats with urinary obstruction, over time serum creatinine decreased, urine creatinine increased, urinary gamma-glutamyl transferase index did not change significantly, and kidney injury molecule-1/urinary creatinine ratio increased. CLINICAL SIGNIFICANCE: Cats with post-renal obstruction and potential intrinsic renal damage had higher urinary gamma-glutamyl transferase index than healthy cats at the time of presentation and showed increase in kidney injury molecule-1/urinary creatinine ratio over time.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34665457/