Peer-reviewed veterinary case report
How long ceftiofur stays in dog tears after injection
By Bowden, Anna Catherine et al.·Published in Frontiers in veterinary science·2022·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Kinetics and minimal inhibitory concentrations of ceftiofur in tear film following extended-release parenteral administration (Excede) in dogs.
- Species:
- dog
Plain-English summary
A group of six dogs received a single injection of a long-lasting antibiotic called ceftiofur (Excede) to see how well it worked in their tear film after their blood-tear barrier was disrupted. The researchers found that ceftiofur levels in the tears were detectable for up to 10 days, but the amounts were too low to effectively fight common eye infections in dogs. This means that while the antibiotic reached the tear film, it may not be strong enough to help with bacterial eye problems. More research is needed to find better dosing or alternative antibiotics for treating eye infections in dogs.
People also search for: dog eye infection treatment · ceftiofur for dogs · antibiotic eye drops for dogs
Abstract
PURPOSE: Describe the pharmacokinetics of extended-release parenteral ceftiofur (Excede) in canine tear film and compare these concentrations to minimal inhibitory concentrations (MICs) of ceftiofur against common ocular pathogens in dogs. METHOD: Six dogs of various breeds were enrolled. Disruption of blood-tear barrier was achieved with histamine-induced conjunctivitis to ensure clinical relevance of the results. Each dog received a single subcutaneous injection of 5 mg/kg Excede, followed by tear collection with Schirmer strips at times 0, 0.25, 0.5, 1, 2, 4, 8, 12, 24, 36, 48, 72, 96, 120, 144, 168, 192, 216 and 240 h. Drug quantification was performed with liquid chromatography-mass spectrometry. MICs were determined forandby assessing bacterial growth (= 10 per bacterial species) in the presence of ceftiofur at increasing concentrations. RESULTS: Blood-tear barrier breakdown provided tear film concentrations of ceftiofur 3.2-28.9-fold higher than in the contralateral healthy eye (= 1 dog, pilot experiment). In all six dogs, ceftiofur concentrations in tears varied from 2.3 to 637.5 ng/mL and were detectable up to 10 days (240 h) after subcutaneous injection. However, tear levels always remained below MICs for common ocular isolates (≥640 ng/mL). CONCLUSIONS: Ceftiofur reached the tear compartment (for up to 10 days) after a single parenteral injection, however tear concentrations were extremely variable and too low to be effective against common bacterial pathogens in dogs. Further studies with different ceftiofur dosage or other long-acting injectable antibiotics are warranted.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36213401/