Peer-reviewed veterinary case report
Kit receptor changes in cats with splenic mast cell tumors
By Sabattini, S et al.·Published in Veterinary and comparative oncology·2017·Department of Veterinary Medical Sciences, Italy·View original on PubMed →
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Original publication title: Kit receptor tyrosine kinase dysregulations in feline splenic mast cell tumours.
- Species:
- cat
Plain-English summary
A group of 22 cats with splenic mast cell tumors (a type of cancer affecting the spleen) was studied to understand the role of certain genetic changes. The average survival time for these cats was about 780 days, with those having tumors only in the spleen living longer than those with more widespread disease. Most tumors showed specific patterns of a protein called Kit, and genetic testing revealed mutations in 65% of the cases. However, the presence of these mutations did not directly relate to how aggressive the tumors were or how long the cats survived.
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Abstract
This study investigated Kit receptor dysregulations (cytoplasmic immunohistochemical expression and/or c-KIT mutations) in cats affected with splenic mast cell tumours. Twenty-two cats were included. Median survival time was 780 days (range: 1-1219). An exclusive splenic involvement was significantly (P = 0.042) associated with longer survival (807 versus 120 days). Eighteen tumours (85.7%) showed Kit cytoplasmic expression (Kit pattern 2, 3). Mutation analysis was successful in 20 cases. Fourteen missense mutations were detected in 13 out of 20 tumours (65%). Eleven (78.6%) were located in exon 8, and three (21.6%) in exon 9. No mutations were detected in exons 11 and 17. Seven mutations corresponded to the same internal tandem duplication in exon 8 (c.1245_1256dup). Although the association between Kit cytoplasmic expression and mutations was significant, immunohistochemistry cannot be considered a surrogate marker for mutation analysis. No correlation was observed between c-Kit mutations and tumour differentiation, mitotic activity or survival.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27278268/