Peer-reviewed veterinary case report
How fast Credelio kills Ixodes ricinus ticks on dogs
By Murphy, Martin et al.·Published in Parasites & vectors·2017·Elanco Animal Health·View original on PubMed →
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Original publication title: Laboratory evaluation of the speed of kill of lotilaner (Credelio™) against Ixodes ricinus ticks on dogs.
- Species:
- dog
Plain-English summary
A study found that a new chewable tablet called lotilaner (Credelio) effectively kills Ixodes ricinus ticks on dogs. In the trial, dogs treated with lotilaner showed a 69.8% reduction in live ticks just 4 hours after taking the medication, and this increased to 100% within 8 hours. The treatment continued to be effective for at least 35 days, significantly reducing tick counts compared to untreated dogs. Importantly, there were no side effects reported from the treatment. Lotilaner could be a great option for pet owners looking to protect their dogs from ticks and the diseases they carry.
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Abstract
BACKGROUND: With the geographical expansion of tick species and increased recognition of pathogens they transmit, there is a requirement for safe and rapidly effective control measures for dogs. Lotilaner, a novel isoxazoline, is rapidly absorbed following administration of a flavored chewable tablet formulation (Credelio™), providing at least 98% efficacy for at least 1 month following assessments at 48 h post-treatment, and following subsequent challenges. A study was conducted to determine the speed with which lotilaner kills ticks. METHODS: From 38 dogs, the 32 with the highest Ixodes ricinus counts from a Day -4 infestation were randomized among four groups: two groups were untreated controls, two received lotilaner tablets at a minimum dose rate of 20 mg/kg. Infestations with I. ricinus were performed on Days -2, 7, 14, 21, 28 and 35. Counts were completed 4 and 8 h post-treatment (Day 0), and 8 and 12 h following subsequent infestations. All live ticks were incubated for 24 h following removal from study dogs. RESULTS: At 4 h post-treatment, there was a 69.8% reduction in geometric mean live tick counts in treated dogs compared to controls. After incubation, the reduction increased to 97.2%. At 8 h after treatment, pre- and post-incubation reductions were 99.2 and 100%, respectively. Following post-treatment challenges, post-incubation efficacy through Day 28 at 8 and 12 h was at least 94.3 and 98.0%, respectively, and was 85.7 and 94.2% at 8 and 12 h after the Day 35 challenge. Mean live tick counts in the lotilaner groups were significantly lower than in the control groups at all assessments through Day 35 at 8 (t ≥ 9, P < 0.0001, Days 0 to 28; t = 3.54, P ≤ 0.0095, Day 35) and 12 h post-treatment and after subsequent infestations (t ≥ 10, P < 0.0001, all days). There were no treatment-related adverse events. CONCLUSION: Lotilaner at a minimum dose rate of 20 mg/kg began to kill ticks on dogs within 4 h of treatment and efficacy was 100% within 8 h. Lotilaner sustained a rapid kill of newly infesting I. ricinus through 35 days. By quickly killing ticks that infest dogs, lotilaner has potential to help limit the transmission of tick-borne pathogens.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29089039/