Laboratory models of regional chemotherapy.

Abstract

Development of new treatment strategies and agents is a difficult and costly matter in oncology. Routinely drugs are tested in vitro on tumor cells which, however, may have limited predictive value for their activity in patients. Also, the pharmacokinetic behavior, intratumoral distribution, as well as toxic side effects, binding to other compounds and stability of an agent are very important in determining activity in the patient. More so, development and evaluation of surgical delivery methods, i.e. regional treatment strategies, cannot be tested in cell systems. Therefore animal models are crucial for the development of regional chemotherapy methodologies. To allow translation of the animal data to patients it is important that the animal model closely mimics the clinical setting as for instance is achieved with isolated limb perfusion. However, animal models remain limited in their use, as eventually the efficacy of the approach may be different in animals compared to patients. Here we describe the use of animal models for regional treatment of solid tumors.