Peer-reviewed veterinary case report
No skin-specific IgE autoantibodies found in dogs with severe atopic
By Olivry, Thierry et al.·Published in Veterinary immunology and immunopathology·2008·North Carolina State University, United States·View original on PubMed →
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Original publication title: Lack of detection of circulating skin-specific IgE autoantibodies in dogs with moderate or severe atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of 19 dogs with moderate to severe skin allergies (atopic dermatitis) were tested for specific antibodies in their blood that might indicate an immune reaction to their own skin. Researchers used various methods to look for these antibodies but found none in the dogs' blood samples. This suggests that either these antibodies are not present in dogs with this condition or that the testing methods were not sensitive enough to detect them. The study indicates that the immune response in dogs with atopic dermatitis may differ from that seen in humans.
People also search for: dog skin allergies treatment · atopic dermatitis in dogs · dog allergy testing methods
Abstract
Human patients with atopic dermatitis (AD) commonly exhibit IgE reactivity to cutaneous self-antigens. The presence of serum IgE autoantibodies appears to correlate with disease severity, and it is suspected to reflect or contribute to tissue damage. The objective of this study was to determine whether IgE autoantibodies specific for cutaneous antigens could be detected in the serum of dogs with AD. Serum was collected from 19 dogs with untreated moderate to severe AD and four specific-pathogen free (SPF) dogs. Indirect immunofluorescence was performed using normal canine skin collected at four different locations (concave ear, nose, medial thigh and lateral thorax), while Western immunoblotting was done using normal canine ear pinna epidermal and dermal extracts and reducing conditions. In both methods, IgE was detected using a monoclonal antibody specific for heat stable epitopes of canine IgE. At 1:10 dilution, specific IgE autoantibodies against cutaneous autoantigens were not detected, with either method, in AD and SPF canine sera. Either IgE autoreactivity is not associated with moderate to severe AD in dogs, or the methods employed herein were not sensitive enough to permit IgE autoantibody detection.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18068810/