Peer-reviewed veterinary case report
Topical regenerative agent did not speed healing of dog corneal ulcers
By Sebbag, L et al.·Published in Veterinary journal (London, England : 1997)·2018·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Lack of effect of a topical regenerative agent on re-epithelialization rate of canine spontaneous chronic corneal epithelial defects: A randomized, double-masked, placebo-controlled study.
- Species:
- dog
Plain-English summary
A group of dogs with chronic corneal ulcers, known as spontaneous chronic corneal epithelial defects (SCCEDs), were treated with either a special topical regenerative agent or a placebo to see if it would help their eyes heal faster. After monitoring the healing process, the researchers found that both treatments took a similar amount of time to heal, with no significant difference in effectiveness. The average healing time was about 17 days for the regenerative agent and 19 days for the placebo. Although the regenerative agent was safe for the dogs, it did not provide any additional benefits for healing these eye ulcers.
People also search for: dog eye ulcer treatment · SCCED in dogs · corneal ulcer healing time
Abstract
Spontaneous chronic corneal epithelial defects (SCCEDs) are characteristic ulcers in dogs that are refractory to healing. The aim of the study was to evaluate the use of a topical regenerative agent to promote healing of SCCEDs. Nineteen dogs (20 eyes) were randomized to receive either regenerative agent (10 eyes) or placebo (10 eyes) every 48h following corneal debridement, which was repeated 1 week later if the SCCED had not yet healed. The mean±standard deviation time to re-epithelialization was 17.3±12.8 days for the group treated with a topical regenerative agent and 19.3±11.7 days for the group treated with a placebo; the cumulative healing rates were not statistically different (P>0.650). A positive association was found between the initial size of the ulcer and the time to re-epithelialization (r=0.555, P=0.011). Although well tolerated by dogs, there was no therapeutic advantage in using a topical regenerative agent for re-epithelialization of SCCEDs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29486881/