Peer-reviewed veterinary case report
Lack of in vitro biofilm formation does not attenuate the virulence of Streptococcus gordonii in experimental endocarditis.
- Journal:
- FEMS immunology and medical microbiology
- Year:
- 2006
- Authors:
- Bizzini, Alain et al.
- Affiliation:
- Department of Fundamental Microbiology
Abstract
The ability to induce experimental endocarditis of biofilm-deficient mutants of Streptococcus gordonii was studied in an isogenic background. Strains were inactivated in either comD, fruK or pbp2b genes, which are involved in biofilm formation. These strains were clearly impaired (>75% reduction) in biofilm production in vitro. However, this did not result in a decreased severity of infection in vivo.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17087816/