Peer-reviewed veterinary case report
Lack of influence of the anaerobic [NiFe] hydrogenase and L-1,2 propanediol oxidoreductase on the outcome of Actinobacillus pleuropneumoniae serotype 7 infection.
- Journal:
- Veterinary microbiology
- Year:
- 2004
- Authors:
- Baltes, Nina et al.
- Affiliation:
- Department of Infectious Diseases · Germany
Abstract
The genes for the large subunit of [NiFe] hydrogenase 2, (hybB) and for L-1,2 propanediol oxidoreductase (fucO), were identified in an Actinobacillus (A.) pleuropneumoniae serotype 7 strain. Based on the hypothesis that adaptation to anaerobic conditions in damaged lung tissue may play a role in A. pleuropneumoniae persistence in host tissues, deletion mutants with a deletion in the hybB or the fucO gene were constructed and examined in an aerosol infection model. Deletion of the hybB or fucO genes appeared to have no significant effect on A. pleuropneumoniae virulence.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15288928/