Peer-reviewed veterinary case report
Lack of neuropeptide Y attenuates the somatic signs of opiate withdrawal.
- Journal:
- Synapse (New York, N.Y.)
- Year:
- 2006
- Authors:
- Olson, Valerie G et al.
- Affiliation:
- Department of Biochemistry · United States
- Species:
- rodent
Abstract
Recent evidence suggests that neuropeptide Y (NPY) may be involved in the neurobiological responses to drugs of abuse. This study was designed to assess the possible contribution of NPY to opiate withdrawal behaviors. Here we report that mice lacking the NPY gene show normal conditioned place aversion to opiate withdrawal, but show attenuated opiate withdrawal somatic signs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16952158/