Peer-reviewed veterinary case report
Lactate administration improves laboratory parameters in murine models of iron overload.
- Journal:
- Blood
- Year:
- 2024
- Authors:
- Liu, Wei et al.
- Affiliation:
- Shandong First Medical University and Shandong Academy of Medical Sciences · China
- Species:
- rodent
Abstract
Current iron overload therapeutics have inherent drawbacks including perpetuated low hepcidin. Here, we unveiled that lactate, a potent hepcidin agonist, effectively reduced serum and hepatic iron levels in mouse models of iron overload with an improved erythropoiesis in β-thalassemic mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38194678/