Peer-reviewed veterinary case report
LACTATEing Salmonella: A Host-Derived Fermentation Product Fuels Pathogen Growth.
- Journal:
- Cell host & microbe
- Year:
- 2018
- Authors:
- Stecher, Bärbel & Jung, Kirsten
- Affiliation:
- Max von Pettenkofer Institute of Hygiene and Medical Microbiology · Germany
Abstract
Infection by Salmonella enterica serovar Typhimurium is accompanied by dysbiosis and a decrease of microbiota-derived butyrate. In this issue of Cell Host & Microbe, Gillis et al. (2018) demonstrate that the lack of butyrate reprograms colonic epithelial metabolism toward lactate fermentation. Lactate is then used as a respiratory electron donor, supporting Salmonella growth and thus promoting infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29324228/