Peer-reviewed veterinary case report
Probiotic Lactobacillus salivary may help antibiotic-resistant
By Zhang, Ting et al.·Published in Probiotics and antimicrobial proteins·2026·College of Veterinary Medicine, China·View original on PubMed →
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Original publication title: Lactobacillus salivary LSbg3 is a Potential Food Probiotic Having Excellent Anti-pathogen Effect That Might Improve Antibiotic-Resistant Diarrhea in Dogs.
- Species:
- dog
Plain-English summary
A study found that a specific strain of probiotic bacteria called Lactobacillus salivarius LSbg3 could help dogs with diarrhea that doesn't respond to antibiotics. This strain was shown to be safe and effective at restoring balance in the gut and fighting harmful bacteria. In tests simulating diarrhea in dogs, LSbg3 helped reduce symptoms and improve gut health without carrying antibiotic resistance. This suggests that it could be a beneficial addition to the diet of dogs suffering from antibiotic-resistant diarrhea.
People also search for: dog diarrhea treatment · probiotics for dogs · antibiotic-resistant diarrhea in dogs · Lactobacillus for dogs
Abstract
Antibiotics may disrupt the intestinal microbiota balance and induce antimicrobial resistance. Although probiotics should be a priority treatment for animal diarrhea, it still has chance to be used as same/or behind as antibiotics in the clinic. Among the probiotics, Lactobacillus (Lact.) was the most frequently utilized in clinical setting since its excellent ability of safety, anti-pathogen, stress resistance, and easy colonization in intestine. In this study, we screened 24 strains of Lact. in the presence of antibiotics from clinical common antibiotic-treated feces, identified L. salivarius LSbg3 exhibiting good stress resistance, potent antibacterial activity, and exceptional intestinal adhesion capability. Its genome showed a good function of regulating intestinal nutrition while lack of transmission antibiotic-resistance genes. Additionally, in a simulated canine diarrhea with failed antibiotic treatment, LSbg3 had a good efficacy in the releasing diarrhea, balancing the microbiome and suppressing typical pathogens, positioning a potential food probiotic have excellent effect on anti-pathogen that can effectively improve antibiotic-resistant diarrhea in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40259196/