Peer-reviewed veterinary case report
Protein therapy improves muscle repair in dogs with muscular dystrophy
By Barraza-Flores, Pamela et al.·Published in Human molecular genetics·2019·Department of Pharmacology, United States·View original on PubMed →
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Original publication title: Laminin-111 protein therapy enhances muscle regeneration and repair in the GRMD dog model of Duchenne muscular dystrophy.
- Species:
- dog
Plain-English summary
A group of golden retriever dogs with muscular dystrophy, a condition that causes muscle weakness and degeneration, received injections of a protein called Laminin-111 to see if it could help their muscles recover. After treatment, the dogs showed improved muscle strength and better muscle repair, with less damage to their muscle fibers. This suggests that Laminin-111 could be a promising new therapy for dogs suffering from this serious muscle disease.
People also search for: golden retriever muscular dystrophy treatment · dog muscle weakness therapy · Laminin-111 for dogs
Abstract
Duchenne muscular dystrophy (DMD) is a devastating X-linked disease affecting ~1 in 5000 males. DMD patients exhibit progressive muscle degeneration and weakness, leading to loss of ambulation and premature death from cardiopulmonary failure. We previously reported that mouse Laminin-111 (msLam-111) protein could reduce muscle pathology and improve muscle function in the mdx mouse model for DMD. In this study, we examined the ability of msLam-111 to prevent muscle disease progression in the golden retriever muscular dystrophy (GRMD) dog model of DMD. The msLam-111 protein was injected into the cranial tibial muscle compartment of GRMD dogs and muscle strength and pathology were assessed. The results showed that msLam-111 treatment increased muscle fiber regeneration and repair with improved muscle strength and reduced muscle fibrosis in the GRMD model. Together, these findings support the idea that Laminin-111 could serve as a novel protein therapy for the treatment of DMD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31179490/