Peer-reviewed veterinary case report
Laparoscopic kidney nerve cutting lowers blood pressure
By Shao, Chunlai et al.Ā·Published in BMC cardiovascular disordersĀ·2020Ā·Department of Cardiology, ChinaĀ·View original on PubMed ā
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research ā every detail traces back to the citation above. How we work ā
Original publication title: Laparoscopic based renal denervation in a canine neurogenic hypertension model.
- Species:
- dog
Plain-English summary
A group of 16 Beagle dogs with induced high blood pressure underwent a procedure called laparoscopic renal denervation (L-RDN) to see if it could help lower their blood pressure. After eight weeks, the dogs that received the L-RDN treatment showed a significant drop in both systolic and diastolic blood pressure, while the control group that did not receive the treatment did not see any improvement. Additionally, the L-RDN group had lower levels of norepinephrine, a hormone linked to stress and blood pressure, without any noticeable damage to their kidneys. This suggests that L-RDN can effectively reduce high blood pressure in dogs without harming kidney function.
People also search for: dog high blood pressure treatment Ā· Beagle renal denervation Ā· laparoscopic surgery for dog hypertension
Abstract
BACKGROUND: Previous renal denervation (RDN) studies showed controversial results in reducing blood pressure. The aim of this study was to provide evidence supporting the effectiveness of laparoscopic-based renal denervation (L-RDN) in treating hypertension. METHODS: Sixteen Beagle dogs were randomly divided into RDN group (n = 12) and sham group (n = 4). Neurogenic hypertension was generated in all dogs via carotid artery route. L-RDN was performed in the RDN group, with sham operation performed as a control. Blood pressure (BP) changes were recorded at 2, 4, 6, and 8 weeks after the procedure. Changes in serum creatinine (sCr), blood urea nitrogen (BUN) and level of norepinephrine (NE) were analyzed. Histological changes of kidney and renal arteries were also evaluated. RESULTS: BP and NE levels were significantly elevated after hypertension induction (p < 0.01). Systolic and diastolic BP of RDN group were decreased by 15.5 mmHg and 7.3 mmHg (p < 0.0001 and p = 0.0021, respectively) at the eighth week after L-RDN. Invasive systolic and diastolic BP of RDN group were significantly decreased by 14.5 mmHg and 15.3 mmHg (p < 0.0001). In contrast, there was no significant decrease in blood pressure in the sham group. In addition, RDN group but not the sham group showed a significant decrease in NE levels (p < 0.001), while no significant changes in sCr and BUN were observed in both groups. Pathological examinations showed no discernible damage, tear, or dissection to the renal arteries in RND group. CONCLUSIONS: L-RDN lowered BP and NE levels in hypertensive dogs without affecting renal artery morphology and kidney function.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32527220/